I wouldn't.
While i'm sure there would be some interesting stuff on the series and/or film with or without him, and I am a fan of all the major cast, i'd see it as yet another slight for the first (and as yet only) non-white series lead.
Moreover, i'm one of the (seemingly few) fans here who think that the inner life of say, Damar, or Garak, or Zek is NOT as interesting and compelling as the 7 year journey of a man who starts out as a broken, somewhat embittered officer who doesn't even want to be on DS9, to one who feels that DS9 is "the place where I belong" ("A Call to Arms"). And I also prefer secondary characters, however interesting, to remain well, secondary characters.
I enjoy how certain secondary characters come to the fore in DS9, notably Garak, Nog and at last Damar, but otherwise I echo your sentiments for the most part.
While (to its credit) DS9 remained a true ensemble show throughout, Sisko, Kira and Odo are at the core of the saga, with Quark as a sort of stable pivot point at the middle of it all, like the station itself. These to me are the show's most important, most fully-realized characters, and they are the ones that interest me the most. (In fairness to my Cardassian-loving brethren, I do think Garak and Dukat are next on this list)
This.
I know it is a bit of a nitpick, but I always find myself getting annoyed when people list Worf/Michael Dorn in the cast credits ahead of Odo/Rene Auberjonois. I'm like "no, people, ODO is the third of the series' BIG THREE. Put Worf fourth". Just sayin...
For the record, I enjoy most of the series' secondary characters as well. Clearly the series' would not be the same without them. Martok, Nog, Dukat, Garak, Winn etc. were a great reason the show was as good as it was.
I just tend to get impatient when the writers (as sometimes happened in Season 7), forget that these characters are not ends unto their own, but ideally, well-realized catalysts helping to drive the central characters and plots.