Yes. And the old Gold Key ST comics were frequently "weird, but not in a good way," with more than a few stories that seemed like they had to have been written by people who'd never seen the series, and barely had a clue what it was about.
Well, we're speaking more in terms of unusual crossovers, and that's pretty normal for comics. Comics universes tend to be a hodgepodge of genres and tropes that would normally never go together -- gritty noir detectives live in the same world and fight on the same teams with technological masterminds, pulpy space aliens, fourth-wall-breaking comedy characters, and straight-up sorcerors and gods. Comic-book universes are defined by their syncretism, their willingness to combine things normally kept separate and to experiment with unusual blends and reinterpretations.