I don't do much Trek reading nowadays, but I did read The Q Conflict comic trade paperback yesterday. It was pretty fun, with Q and several other non-corporeal races (Organians, Metrons and Trelane) solving a conflict by selecting teams from basically the TOS/TNG/DS9/VOY crews to compete in challenges. We get a bunch of character interactions that we'd never get to see, like Janeway and Chekov, although it doesn't really get into stuff like Nemesis era Worf being around DS9 season 3 Jadzia.
It did end a bit weirdly, maybe because IDW was doing ongoing comics that needed this to happen but right at the end we get Wesley Crusher and Amanda Rogers (who had been secretly helping the Starfleet Officers) randomly get their powers stripped and turned back into regular humans, which not only seems pointless but came out of nowhere. It means nothing to the story in the comic and doesn't match up with any other story or continuity (although obviously this comic came out before Wesley appeared in Picard S2 ands Prodigy). I can only guess that IDW was planning to do something with those characters in other comics, but taking The Q Conflict as a standalone story it was a bizarre, rushed part of the ending.
Still it was a great comic overall, and you don't need anything more then basic Trek knowledge to read and enjoy it, even if it has a few odd continuity issues.