<shrug> Theatrical productions don't tend to be blockbusters in the common parlance, but they're no less culturally significant.
However, West Side Story would be one very prominent example, Romeo+Juliet, featuring a black Mercutio, and Romeo Must Die. How about Bollywood productions?
For Homer, you've got, at a Wiki glance, James Joyce (Ulysses), Sinbad the Sailor (though that obviously rather pre-dates "blockbusters"), 2001: A Space Odyssey, O Brother, Where Art Thou, and Cold Mountain.
Also, there's of course Jesus Christ: Superstar, and its' depiction (in the filmed versions) of either Judas or Peter as an African American.