If the Founders had no further plans to conquer the AQ, I think they would try to destroy the wormhole as a (preemptive) defensive measure.
I don't think they'd need to do so.
Right now, the entire Alliance was needed to defeat just an isolated outpost of the Dominion. And had the wormhole aliens not stretched out a helping hand by making those 2700 ships disappear (and making the outpost 'isolated' for the rest of the war), they would have lost this war without any prayer of hope. This outpost might have been a relatively minor affair in the grand scheme of Dominion politics and troop deployments- we don't know. So right now, the Dominion is probably very comfortably ahead and there's no way the Alliance could pose any threat to the Dominion. (Well, apart from any nefarious schemes such as that morphogenetic virus.)
However, given the speed with which the Federation develops, and some indications that the Dominion seems to be in a technological stasis, or at least to progress very, very slowly, the Federation (or the Alliance) might be able to stand up to the Dominion itself in a century or so. Incidentally, that's also the timeframe Q gives for the first presence of humans in the DQ, so by that time, the wormhole being destroyed or not probably becomes gradually less of a factor.
So all in all, whether they destroy the wormhole or not, they are probably still 'safe' for a century after DS9, but no more than that. Given that the Dominion plays 'the long game' they would take all this into consideration.
How could they? It's in their playbook.I doubt the dominion would forget a little thing like attempted genocide.
Perhaps that's why the Prophets took Sisko with them: to make him work the wormhole's customs desk.But they probably set up a military post at the wormhole’s entrance to enforce the terms of the treaty.
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