Speaking of guest stars, I'm wondering if we might see Patrick Stewart eventually. His CIA boss is a major recurring character on American Dad, he's done several TNG cutaways on Family Guy, and he was the narrator of at least the first Ted (I don't know about 2, I haven't seen it), so he has a pretty good history with McFarlane. Not to mention the obvious Trek connection would make it a lot of fun.
Honestly, I think I'd rather see Trek actors doing cameos and guest roles on The Orville, even more than I would on Discovery.