2379 (post-Nemesis)
Picard realized that he missed Crusher when she left for Starfleet Medical. He also realizes that he has less time ahead of him than behind and that he's had two full and lengthy commands. He accepts a second offer to become commandant of Starfleet Academy and asks Beverly to marry him. Despite the years since their neural link, she reveals she's been wondering what took him so long.
I promise this was an idea I had years before Picard: Geordi realizes that the only way to restore Data from his backup to B-4 is with a more advanced android. The only Soong type android that fits the bill is Lore. Geordi restores Lore and offers him a choice: continued non-existence or the chance to make up for his past misdeeds and give his brother a second chance at life. Lore agrees, and while he is overwritten entirely by Data's matrix, Data retains Lore's memories. He also gains access to emotions as a result of inhabiting Lore's body and discovers that Lore also had a subroutine which, when activated, allows him to appear as if he's aging like a human.
Data takes time to process his rebirth and new emotions. Worf is promoted to captain of the Enterprise-E. Riker and Troi continue on the Titan, welcoming children in a few years' time.
2399
The Picards, Rikers, LaForges, Worf, and Data gather for a reunion celebrating the 30th anniversary of their first voyage together as the command crew of the Enterprise-D. Their children are also present, including Jean-Luc and Beverly's son, Robert Rene William Picard, Will and Deanna's children, Jean-Luc Kyle Thomas Riker and Kestra Lwaxana Riker, and Geordi and Leah's children, Alanna, Bret, and Sydney. Bret and Alandra are Starfleet cadets along with Robert, Jean-Luc, while Kestra and Sydney are pursuing different career paths.
The reunion coincides with the maiden voyage of the Enterprise-F, under the command of Captain Data. The ship launches from Starbase One for a short voyage to Alpha Centauri where additional crew will be onboarded. Once the ship jumps to warp, however, something malfunctions in the warp core. The engines create a tear in space that pulls the Enterprise-F inside. The ship is deposited into a strange dimension that resembles one of the distant galaxies visited by the Enterprise-D in "Where No One Has Gone Before."
Of course, the engines overload, and the ship is stranded. Generations new and old must work together to determine what really happened (hint: Q) and overcome threats to their bodies and very souls that no one could ever imagine. Many old faces appear in the process, and perhaps Travelers stop by to offer assistance.