Drake Bell, huh? If I recall correctly, I just saw him playing a grown-up Timmy Turner in the live-action Fairly Oddparents movie Nickelodeon just did. I thought he was okay, but not great; his vocal performance was a little bit bland. But maybe in animation he'll put more life into it. I gather he's a singer, so he should be able to use his voice expressively. Still, Josh Keaton's Spidey is a hard act to follow. (And an interesting coincidence, Steven Weber played the villain in that Oddparents movie, so that'll be twice he's played an evil industrialist nemesis to Bell's hero character.)
It's cool that Agent Coulson is getting a life outside of movies; that's the first step toward pulling a Harley Quinn (or a Renee Montoya, or, heck, a Jimmy Olsen) and getting added to the comics. But it's a bit weird that the breakout character of the Marvel Studios movie universe is appearing in a version of Spider-Man, a character that Marvel Studios can't make movies about because Sony has the rights. Sure, I know that Sony sold the TV rights for Spidey back to Marvel (which is the whole reason Spectacular was cancelled and we're getting this instead, which I'd be a lot angrier about if it hadn't led to Greg Weisman getting a gig on Young Justice), but it still seems weird.
Although it would be interesting if this show were kept consistent with the Marvel Studios movieverse (or the Avengers movieverse, I guess you could call it). Maybe this could be the version of Spidey that exists in that universe, as distinct from the version that exists in the Raimi films' universe and the one that exists in the upcoming film's universe. But I doubt that'll happen. Keeping a TV series consistent with an ongoing film series, let alone multiple film series from different directors, would be a logistical nightmare. More likely it'll be in its own continuity that just kinda sorta resembles the movies but won't be honored by them (like the way the CGI Spidey series purported to follow the continuity of the first Raimi movie but was contradicted by the second movie).