Lines you just can't forget...

[Paradon]

Damar: "All this talk of gods and prophets strikes me as nothing more than superstitious and nonsense".
Weyoun: "It is superstitious and nonsense".
Damar: "You believe the Founders are gods, don't you"?
Weyoun: "That's different"!
Damar: [laugh] "In what ways"!
Weyoun: "The Founders are gods"!

 

[Anji]

Worf - "Today is a good day to die, and the day is not yet over."

I don't think you can get any tougher than that.

 

[Mr. Laser Beam]

"I...hate...Ferengi." (dies)

 

[Scott1768]

"I am attempting to construct a mnemonic device from stone knives and bearskins." - Spock

 

[T'Girl]

"Who's been holding up the damn elevator?"

Slightly earlier, while not exactly a "line," the look Saavik gives Kirk in the lift. The way her eyes tell Kirk; "what are you waiting for, tear off my fukk clothes ... here, I'll put my hands behind my back for you."

I mean really!

 

[Herkimer Jitty]

"Logic is a little tweeting bird, chirping in a meadow. Logic is a wreath of pretty flowers which smell bad."

 

[Tora Ziyal]

"You may now give birth."

My all-time favorite (humorous) line from any series.

 

[Admiral Shran]

SULU: "Target that explosion and fire."

 

[OldManDax]

Major Kira in "Emissary"

"You’re probably right Jasad and if you were dealing with a Starfleet officer they would probably admit we have a hopeless cause here. But I am just a Bajoran whose been fighting a hopeless cause against the Cardassians all her life so if you want a war, I’ll give you one.’

That scene always give me chills.

Captain Sisko in "A Call to Arms"

"And I promise you, I will not rest, until I stand with you again - here, in this place where I belong."

An awesome declaration of absolute intent and clarity on Sisko's part, that has a nice, almost poetic feel to it, especially considering Sisko's personal journey over his time in DS9, and the fact that he did not want to be there in the beginning.

 

[Scrambo]

McCoy: "Im trying to thank you, you pointed earred hobgoblin!"

 

[Mr. Laser Beam]

"Sir, there is a multilegged creature crawling on your shoulder."

 

[Amaris]

There are two I can think of immediately. Both are from the TNG episode "Lower Decks":

[scene in Ten Forward - Worf is speaking to Sito Jaxa, as the other officers sit at a table nearby observing]

Lavelle: I wonder what he's saying to her.
Taurik: Did you ever consider learning how to lip read?
Lavelle: You think Worf's chewing her out?
Ben: No, he always looks like that.

And a few moments later...

Lavelle: Riker? I bet he sleeps in his uniform.
Ben: You only think that because he's your C.O. You'd really like him if you got to know him.
Lavelle: Right.
Taurik: He is convinced Commander Riker doesn't like him.
Ben: Why? Did you crash the ship into something?

It's the expression on Ben's face that really sells it.

 

[Iliana Malek]

Bashir: What I want to know is, out of all the stories you told me which ones were true and which ones weren't?
Garak: My dear doctor...they're all true.
Bashir: Even the lies?
Garak: Especially the lies.

 

[Amaris]

[Star Trek TNG: "Captain's Holiday"]

[Picard is trying to relax in the sun]
[A Risan named Joval picks up Horga'hn]

Joval: "The Horga'hn is the Risian symbol of sexuality. To own one is to call forth its powers. To display it is to announce you are seeking jamaharon."
Picard: *sigh* "Riker!"
Joval: "Do you seek jamaharon?"
Picard: "I don't even know what it means. The Horga'hn is for a friend."
Joval: "I see. Someone close to you?"
Picard: "That's right."
Joval: "Someone you love?"
Picard: "I wouldn't go that far."

I can't hear that line without nearly peeing myself.

 

[Caesar753]

Worf: "Death to the opposition!" (Take Me Out to the Holosuite)

 

[klingonhybrid]

Anything a vulcan says, half of what klingons say

 

[HaventGotALife]

"Q the liar! Q the misenthrope!
"Q the miserable, Q the desperate! What must I do to convince you people?!"
"Die."
"Oh, very clever, Worf. Eat any good books lately?"

 

[Arpy]

"We have engaged the Borg." - chills, damn you, chills!!!

 

[Kes2370]

"My gift to you"

"Do It"

"If you have something to say SAY IT"

"Make it so"

 

[Cakemixo]

Picard: If we're going to be damned, let's be damned for who we really are.

Picard: The courtroom is a crucible. In it we burn away irrelevencies untill we are left with a pure product -the truth, for all time.

Odo: With all this lip smacking, who can hear anything?

And many more.