^Did they ever make it clear how many doses you have to take before withdrawal kicks in? I can't remember. I would assume it's more than one.
I really like how the show balances the threat (the senator, the drug, the bad guys) with the just plain goofiness. It makes it more interesting.
It also makes sense, since Brian is a goofball, we see things from his perspective. He's immature, sarcastic, and has a wild imagination. As long as the show isn't wildly goofy all the time, it should at least keep it more interesting than all the boring "procedurals" already out there.