I'm not the biggest fan of Harry Mudd to begin with (or Roger Carmel for that matter), so I generally don't enjoy the stuff he's in. Mudd's Women was a craptacular episode (thank God it wasn't picked as the pilot), and because of Carmel and the over baked comedy, I, Mudd is usually bypassed by me during my episode viewings.
I was never fond of the "all comedy" episodes of Trek. Out of all of them, The Trouble With Tribbles works best for me, since everyone stays in character. I, Mudd and A Piece of the Action, on the other hand, are not so good. A Piece of the Action is just bloody awful with only one good bit from Spock ("I'd advise yas ta keep dialin', Oxmyx.").
It always seemed like everyone went over the top for comedy on the original series. I found Trek's humor to be most successful when it was character based and hauled out to relieve the tension. Not, however, as episode cappers like in The Galileo Seven, where everyone is pissing themselves with cheesy fake laughter after two crewmembers are horribly killed on the planet. Kirk is busting a gut, Bones wipes his eyes, and Scotty is holding onto the turbolift doorway, unable to stand because it's all just so darned funny.
But, yeah, not a fan of The Mudd's.