The problem is that such replicating entities are essentially lifeforms (life on Earth being based on evolved, spontaneously created nanotechnology) and might well mutate into a form where the stop signal no longer works. There was an episode of
Doomwatch (
The Plastic Eaters) back in the 1970s that imagined having to deal with genetically engineered plastic-eating bacteria running amok. One might do well not to release such technology, whether biological or engineered, into the environment. Many of the molecules in our bodies such as proteins, RNA, and DNA are long-chain condensation polymers and something that comes along and disrupts those molecules would be bad news. Nevertheless, research is being done in this area. Let's keep our fingers crossed...
The Race To Develop Plastic-Eating Bacteria (forbes.com)