Qpid
Worf: I protest. I am NOT a merry man!
The Outrageous Okana
Guinan: Data, you spoiled the joke. Now, it could've been your timing.
Data: My timing is digital.
The Corbomite Maneuver
McCoy: What am I, a doctor, or a moon shuttle conductor?! If I jumped everytime a light came on around here, I'll end up talking to myself. (Which of course he is.)
Star Trek IV: The Voyage Home
McCoy: You mean I have to die to discuss your insights on death?
Spock: Forgive me, doctor. I am receiving a number of distress calls.
McCoy: I don't doubt it.
Star Trek VI: The Undiscovered Country
Chang: To Be or Not To Be - that is the question which preoccupies our people, Captain Kirk. We need breathing room.
Kirk: Earth, Hitler, 1938.
Chang: I beg your pardon?
I always get a huge laugh out of this. I love how the entire table is at a deadpan stare directly at Kirk after he says that.
Spock: There is an old Vulcan proverb; "Only Nixon could go to China."