While I have reservations concerning Worf/Dax (I have reservations about most DS9 relationships except for Sisko/Kassidy), most of Worf's other character interactions on DS9 were spot-on. People didn't get him, many didn't like him and the feeling was mutual. Worf and Bashir, for example, never really became friends and as for Quark...
In his book, The Dreams Our Stuff Is Made Of, Thomas Disch criticized Trek brutally for being nothing more than a glorification of corporate office culture. While not necessarily agreeing that it's a bad thing, I'd say he was largely correct. TNG gave us the office of corporate training films, where everyone grows to love everybody else because that's the way it is supposed to be. DS9 seemed closer to the way workplaces actually function, where people may not actively like each other but basic respect and devotion to duty allow them to do their jobs.
Again, caricature vs. character.