One thing that I don't think has been mentioned yet: Janeway's "melting" makeup was done in such a way that it looked like she'd had a stroke. It was pretty powerful and disturbing imagery.
The melting makeup effects on everyone are what made the episode so incredibly bizarre. Think about the episode from an outside perspective looking at all the Trek episodes. Even beyond Trek, into sci-fi tv overall, it's just so... weird.
Seven was the only one that looked crappy. The makeup looked hideous (not the way it was intended) against her maroon catsuit and hair. The cobalt catsuit probably would've been better. Janeway had the best makeup job. They should've made Chakotay's tattoo lines bend down and look like they run down part of his temple rather than look cohesive.