"A Sea Change" as it were...
There would literally be no aspect of human life and civilization that would not be affected by such a major breakthrough. The initial investment cost would be high (already is, based on how much has been spent in research) but, as noted above, amortizing that cost over time will bring it down very quickly.
All of the positives are overwhelming to the few negatives - and there are, of course, some negatives. There will be a period of adjustment. Some industries will completely collapse, or have to restructure dramatically. Some people will have to be re-educated since some types of jobs will almost certainly disappear. There will probably be some pollution involved in the process of building reactors (no free lunch folks) and site prep will impact the local environment.
Once you get past those issues, I think it's far beyond worthwhile as fusion solves so many issues and actually take humanity to the next stage of civilization.