It would definitely be a mistake to characterize Andromeda as merely a Star Trek clone. It was nowhere near that limited in its conception. If it was in conversation with Star Trek at all, it was with the goal of going it one better, updating its concepts for the 21st century, and doing things ST hadn't done -- taking a much more hard-SF approach (they had actual JPL propulsion engineer Paul Woodmansee on board as science consultant and actually listened to him, at least while Wolfe was in charge), building a much vaster and far-ranging civilization (founded by aliens 7000 years ago with humans as a relatively junior member, rather than Earth and America being at the center of it all), embracing modern SF ideas like transhumanism, and most of all exploring a post-Trek kind of setting where the Federation-like civilization had fallen. So there was an element of Asimov's Foundation series and Poul Anderson's Terran Empire in the mix as well, and one could also draw comparisons with Iain M. Banks's Culture, another case of a Federation-like civilization that's much, much more alien and vast and ambitiously imagined than the Federation ever was.