The question with that is, who is going to have the balls to attempt such a task? And would they be willing to do an actual reboot, to make things drastically different?
If they rebooted TOS, would they have a bisexual Kirk, Ms Spock and an African-American McCoy? Or would it just be a case of recasting (again) and repackaging stories with new special effects?
The same question was asked when TNG was developed. The outcry from many fans was, "How can you do
Star Trek without Kirk and company?"
And there are degrees of drastic. Here's but one example:
Captain James Kirk - transferring from command of a smaller and more combat oriented Starfleet vessel. He's replacing former ship's Captain, Christopher Pike, who commanded the
Enterprise for its first six years.
Commander Nyota Uhura - she is the ship's Executive Officer and dubious of Pike's replacement. She is an experienced Contact Officer in dealing with alien races.
Lieutenant ILyik Spock - a young Vulcan/Romulan hybrid and ship's Science Officer.
Lieutenant Commander Lenora McCoy - recently assigned as ship's Chief Medical Officer.
Lieutenant Commander Montgomery Scott - a veteran spacer of many years and deeply involved in designing and building the
Enterprise. He has been ship's Chief Engineer since launch and worked closely with Commodore Robert April who directed the new starship program.
Lieutenant S'ulu - a Medusan who must always wear a contact suit. He is the ship's exceptional HelmNav.
Lieutenant Olesya Chekov - ship's Chief of Security.
The setting is the 28th century. The Federation is recovering from a protracted war with the Romulan Empire ending forty years ago, a war that dragged for thirty years. The Federation had been a burgeoning alliance prior to the conflict encompassing many worlds and are now seeking to regroup its alliance. The war ended in a draw and both sides are intent on solidifying their status with current, former and new allies.
The
Enterprise is among the vanguards, dispatched into the Sagittarius Arm to re-establish contact with former allies and resume exploration of unknown regions.
The Klingons - once leaders of a great empire who are rumoured to reside somewhere in the Sagittarius Arm. The Federation and the Romulans are each intent on finding if this mysterious race still exists.
The Andorians - allies of the Federation
The Gorn - allies of the Romulans
From this you have a great deal of familiar elements yet rearranged to some extent. But you're starting with a clean sheet in every other respect. Familar aliens don't have to look exatcly like or anything like what we've already had. The centuries of pre-history (post our contemporary times) becomes completely blank to be rewritten as desired. The science and technology is properly updated and extrapolated further than what we're already familiar with.
You can still have familiar elements. Zefram Cochrane could still have developed the space warp only the when and where he did it could be different. Sleeper ships and fast relativistic ships were used by Earth for a couple of centuries before the development of FTL warp drive. You could have a bit of rare Earth concept thrown in where the Federation was built up over centuries with fewer advanced races. The new Spock could be in a touchy position with some because he carries the blood of the enemy in his veins even though his father (or mother) is Vulcan.
This is but one example of fashioning something that is unmistakably
Star Trek and yet it isn't bogged down by what came before neither does it erase what came before.