TOS: Not have Kirk/Spock/McCoy dominate so much of the show, make it more of an ensemble.
TNG: Less trying to mimic TOS' style in the first couple of seasons.
DS9: End the Dominion War either early in or midway through the seventh season, so there'd be time to deal with the aftermath.
VOY: Realistic consequences based on their situation, i.e. long-term damage to the ship, energy shortages, less of a happy-go-lucky attitude amongst the crew, etc.
ENT: No Temporal Cold War.
TNG: Less trying to mimic TOS' style in the first couple of seasons.
DS9: End the Dominion War either early in or midway through the seventh season, so there'd be time to deal with the aftermath.
VOY: Realistic consequences based on their situation, i.e. long-term damage to the ship, energy shortages, less of a happy-go-lucky attitude amongst the crew, etc.
ENT: No Temporal Cold War.