As the survivors finally get Edwin to open the door for their escape, T-Dog grabs onto her arm, trying to pull her outside the room with her, but she pulls herself back, telling him she's staying. T-Dog tells her "That's INSANE!", attempting to pull her out with him a second time, but she once again resists, saying "No, it's completely sane, for the first time in a long time. I'm not ending up like Jim and Amy." This catches the attention of the rest of the group, as they all look back at her. Jacqui then tells T-Dog "There's no time to argue, and no point -- not if you want to get out. Just get out...get out!" she protests, then pushing T-Dog, but right after she touches T-Dog's face in a kind, motherly manner. Shane then pulls T-Dog out with the rest of the group, and Dale approaches Jacqui with a shocked look on his face. She backs away from Dale, shaking her head no, and then walks to the back of the room. She's then seen witnessing Dale's plead with Andrea to leave with him. As the rest of the group (who have managed to escape the building) are getting in their vehicles, the scene of Dale and Andrea escaping is shown on a monitor, revealing that Jacqui had ultimately decided to stay behind with Jenner, as Dale got Andrea to change her mind. Jenner says "They got out," to which Jacqui responds with a smile, happy that the people who helped her make it so far are able to continue fighting. She looks at Jenner, as they then hold onto each other's hands as the timer ticks down, and the CDC explodes. She died at peace, rather than some of her previous allies whose deaths were painful results of the walkers.