I said it in another thread, but I will say it again.
People only see what they want to see in the Endgame scenes, some see it as making a better world; some see it as playing god and it is all wrapped up in how you see the Janeway character. Admiral Janeway did what she did, the Temporal Integrity Commission didn’t come after her, and Captain Janeway was given a promotion.
We know next to nothing about the world she changed nor the one she created. To say she destroyed lives is pure speculation by some people, you can just as easily say she saved lives too. Mostly Trek stories are guided by the assumption of "Happily Ever After" and the episode implied that this would be a safe assumption on the audience's part.
The truth is individuals have choices; they are responsible for themselves no matter what time line they are in. When Admiral Janeway changed time, everyone got a second chance but their lives still depended on their individual choices. Anything else would mean our lives are charted by unseen forces, and should be set in stone with no individual choice. We change the time line every morning when we get out of bed, does this cause a death somewhere - maybe. Are we responsible for the death, absolutely not.
Every one of Trek's captains changed time. None of them got into trouble for it either and most were rewarded for it.
Brit