I don’t believe so. Earth-167 (Smallville’s Earth) was presumably destroyed along with all the other Earths, but it’s implied they were all subsequently remade. Earth-1, Earth-38, and Black Lightning’s Earth were merged, and it’s subtly suggested that Earth-96’s history was altered to give its Superman a happier ending. The Lois and Clark of the merged Earth-Prime ended up with “boys,” plural, instead of the single infant son they had on Earth-38. But those are the only established changes I can remember. I feel we are to assume the Earths were restored to their original states unless shown otherwise, and I believe the showrunners confirmed that was the intent at the time. (I think they even addressed Earth-167 specifically and assured viewers its Lois and Clark — and their daughters — were still living happily ever after.)