Marvel Team Up--a pure (Lee-admitted) marketing cash grab due to the character's popularity--was launched in March of 1972--a decade after the character's debut, and well after his central personality traits / status were well-established in 106 monthlies and 8 annuals of the parent title published up to that point.
MTU was not designed to be any narrative shift in Spider-Man's loner character / status for the reason stated above. In fact, in the parent title, he was still a loner wanted by the police (implicated in the death of Capt. Stacy, among other "crimes"), and not chasing after anyone to be a boy sidekick wannabe, and one year later, he would be wanted by the police--again--due to the belief he was associated with Norman Osborn's murder. The parent title carried on the drama of a Parker/Spider-Man who knew he was on his own, carried burdens he was not sharing (or seeking to share) with anyone, and he was not chasing after Iron Man (or anyone else) trying to be a Boy Wonder.
The missed point is that Lee, Ditko, Romita, et al. always reinforced the idea that Spider-Man was a loner who--ultimately--had to go his own way (and was one the few Marvel characters in-universe law enforcement viewed as a criminal). The MCU turned him into a boy sidekick wannabe chasing after "Mr. Stark" instead of the emotionally struggling, misunderstood character he was developed to be over the course of decades, thus J.D.'s "knowing and embracing what they are" assertion is nonsense.
Really? Products generated by the ancillary market had no bearing on the creation and development of this comic character whatsoever, no more than the 1967 or 1981 solo Spider-Man cartoons had on the source, similar to Filmation's 1977 The New Adventures of Batman having no influence on the characters or stories in Batman or Detective Comics published at that time.
None.