It'll be just different enough so that it feels like another time but not so different that it looks like a completely different series.
It won't look as different as it could've and should be. Because even now that would mean a complete and total overhaul that they won't have a budget for. Such is the reality of television production. Knowing this, I'll settle for "just different enough". When going this far into the future, it's too easy to have wildly unrealistic expectations.
EDIT: Back in the '80s, the last time Star Trek jumped forward to a brand-new time period, TNG didn't look much different from the TOS Movies. The main bridge looked very different, and the Galaxy Class Starship exterior design obviously looked very different, but everything else in TNG (minus the uniforms) would've looked right at home in the films at the time.