I don't know if it's been mentioned, but this scene always gets to me

Although not played as much for the creepiness factor, there's also "Remember Me", where Beverly gets to see everyone she knows disappear and nobody else remembers them even existing, and she almost doesn't figure it out until it's too late for her.
From an audience perspective it's somewhat played for laughs near the end when it's just her and Picard, but it's another episode that's a total WTF until you see things from The Other Side(tm).
To the excellent sugestions anove I would add the "cosmic horror"-like Doomsday Machine and Space Amoeba which, between them killed millions and devastated whole star systems.
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