There is also the disparity between series threats posed in Avengers 2 and 3 and how they were followed up by light-hearted fluff Ant-Man 1 and 2.
Or look at DCTV. "Grimdark" Arrow, light-hearted Flash (except Barry's constant torment via loss of family members and Caitlin losing her romantic love interest), the oft absurd Legends etc.
Or Marvel TV. Daredevil, Jessica Jones, Iron Fist and Luke Cage all live in NYC. Spider-Man's NYC. They couldn't be more different.
I don't think Soong-type Android is just talking about the difference in storytelling tone, but about the inconsistency in the way the characters are perceived in-universe. If Superman and Batman were known mainly as scary, lethal vigilantes, would there be action figures of them marketed to kids? It's one thing to say that Ant-Man and the Punisher exist in the same universe; it'd be another thing to retcon the Punisher himself into a figure merchandised to children. One is just variety, the other is inconsistency.
But in this case, it's an inconsistency we're okay with, because we prefer the reinterpreted version of the heroes anyway.