I don't think that would ever work. For example, it already stretches the credulity of "geek cred" in BBT when one of the characters makes an EP IV reference, but spells out the full title in the show ("Star Wars Episode IV", or "Star Wars, A New Hope", or some variant thereof) to make sure the "mundanes" who think themselves non-geeks know exactly what they're talking about. Around here, if I just said "SW EP IV", pretty much everyone would know what I meant. Every character on the show would know that too, but for the sake of the audience, they're unconsciously breaking the 4th wall to over-explain something that they should already know. Same thing with any TOS ep. For the most part, I would say something like "Mirror, Mirror", and everyone knows it. On BBT, they would say "The Star Trek Original Series Episode Mirror, Mirror". Ugh...fucking ponderous.
Now, take that into the basement of TRUE geekdom, where the denizens of such a world barely emerge into the sunlight and have a hard time interacting with others because they have zero social skills. The only place they could reasonably function is a sci-fi convention. And like the others have mentioned here, no scientific references to keep it even mildly interesting, fresh and relevent. It would really ONLY be funny to non-geeks, feeling good about themselves that they aren't the pathetic troglodytes on the screen, constantly struggling in quick-to-get-tiresome fish-out-of-water situations, and it would guarantee to be even more offensive to some geeks than BBT is now. It would kill a core demographic that they would hope to acquire. Many geeks have a hard time laughing at themselves, and this would definitely cross the line and cause a geekdom shitstorm (geekstorm?) of biblical proportions, IMO.