You know I've been thinking about Smith's funk over Zack & Miri and I think he may have lost perspective. It's clear that he wanted Zack & Miri to not just do well or even to be the most profitable of his movies... He wanted a hundred million dollar hit. He wanted the same sort of recognition that Judd Apatow gets for making the exact same types of movies that Smith has been making for the last fourteen years and it's clear he thought Seth Rogan was his ticket to doing that.
I'm guessing this is an early-middle age thing that he's going through that's causing this sort of depression in him. He's clearly forgotten that if life had been a little less generous to him he'd still be a clerk at the Quick Stop instead of a successful filmmaker. No he isn't in the same league as Apatow is at the box office but... His movies have never lost money. He's always told the stories that he's wanted to tell. And people have always responded to his way of telling stories. No his fanbase isn't legion it's small but it's also loyal. Trying to throw away his own style in the hopes of aping Apatow is actually a form of artistic dishonesty on his part and brings him a hairsbreadth of being a hack something his detractors have been claiming fraudulently for years.
I know that as he gets older that he thinks he needs to prove himself and a blockbuster is a way of doing that but... He doesn't understand that he's already everything he needs to be and it doesn't matter what the public at large thinks. It matters that he be the best he can be on every script. On every film. On every single project. He needs to be true to himself and not worry about what Judd Apatow is doing.
I think Clerks 2 was easily his most accomplished work. In it he told the truth about being a man in his 30s. Zack & Miri as funny as it is is not as good as Clerks 2 because all it's about is showing that he can be Judd Apatow too if people will just show up. That's unfortunate that he felt the need to go that route when he could have just been happy being Kevin Smith.