It's hard to say because anything we theorize is really just speculation. Any number of things could have been just a bit different and possibly effected a different outcome.TOS deserved a better fate yet just the right things came together to inevitably strangle the series.
I'm not sure it would have been remembered as fondly if it had ended up with 125 or 150 episodes. That there are only 79 episodes, I think left the audience wanting more. It felt incomplete which allowed fandom to take over the universe.
- What if NBC had paid a bit more money for the series and thus given Desilu a bit more per episode?
- What if TOS hadn't been scheduled on Friday nights? What if NBC had given the show a Monday timeslot as initially said for the third season?
- What if GR had opted to stay more involved during the third season?