Fire said:
I would imagine that in a Federation/Romulan war the Federation would deploy sensors super tuned to detect quantum singularities and tetryon emissions and would no doubt deploy an upgraded anti proton beam.
Well generally in warfare a technical advantage does not last long - measure, counter-measure, new measure and so on.
The only real factor in wnning a "total " war - which is what is being described here, is economic strength and ability. Even though the Klingons and Romulans would probably initially have an advantage due to their probably being the attacker and a more militaristic society you would be left with 1942 pretty quickly.
The Fed fleet would have to hold the line until the Federation's huge economy started kicking out ships faster than the Romulans or Klingons could, and then they would turn the tide and fight them all the way back.
I don't think morals would have much to do with it - even in TNG Picard did not flinch at blowing a ship up if he had no choice - in a war the choice is always simpler and the Feds would not be nearly as cuddly.