Personally, I'd love to see a great TNG-era "send off" movie. The final hurrah, featuring mainly the TNG crew, but incorporating people from the other shows.
Its funny, we got the "baton passing" from Kirk and Co. to TNG in Generations . . . and then got the "baton passing" from Nimoy to new cast in Star Trek . . . but the closest we go to a baton passing for TNG guys is a comic book! A GOOD comic book, don't get me wrong . . .
I'd love to see a direct to DVD TNG movie. Do it like they did the BSG movies: premiere on SyFy (

) on Sunday night, then release on DVD the following Tuesday.
Unfortunately, we DID already have an AWESOME TNG send off with "All Good Things". And the impact of that was completely stolen by the TNG movies.
But, yeah, direct to DVD movies (like Stargate/BSG have done) would work, i think. And a compelling story is important. And dire consequences. I understand Janeway was killed off in the follow up novel series.
Let's have Riker and Troi and the Titan get destroyed . . . and Picard on a mission to find out who did it, why, and get revenge . . . maybe. High personal stakes, awesome action, and a proper send off to TNG, DS9, and Voyager. It always bugged me that the show ended when they got home, and we never really got to find out what their life was like . . . it was an alternate timeline we saw, right? it's been a long time.
~ Ben