I personally don't care what Star Trek fans "know" or "don't know" regarding Mass Effect. As a general rule, I would like to avoid it.
The struggle with that, as fair of a point that may be, is that since Star Trek has done it before, I would be hesitant to build it around in another show, especially the origins of humanity. Cliques and factions would be more interesting, especially as a fallout from the Dominion War. I certainly wouldn't like a nihilism faction to become the central focus though. I don't mind challenging the thread of optimism running through Star Trek's various iterations, but nihilism is far to common in contemporary society and media. I would rather see it not take center stage.
As for weapons technology, I wouldn't mind seeing different weapons being employed, or other designs based upon contemporary developments (Direct Energy Weapons, rail weapons and the like. I'm sure I'm missing something).
I think I would prefer to see more innovation with technology, with Federation scientists and Starfleet working to integrate Dominion tech and research to their advantage as they rebuild and explore previously unknown territory (Romulan contraction, Cardassian worlds, or even the Breen).
If it has to borrow from other science fiction, rather than building upon established themes from its own series, then I would rather see it use a marine unit, like Halo or Starship Troopers, or a more frontier element, like Firefly.
The fact that
Star Trek borrows from other works and is turned alluded to by others shows that not following such rule makes no sense.
Next, there is obviously a difference between something that's been done and that's hardly be done. In the case of
Trek, it's mostly the latter for the points that I raised, as much of the franchise has involved exploration, even for those that had a main story arc that encompasses the series (like
Voyager). Film, of course, can be more flexible, especially if one envisions an end to the franchise.
About nihilism being a dominant part of the
Trek series or even science fiction in general, I feel that's it's been the other way round.
Technological development is one of my points and puts to question the argument that a general idea of not alluding to
Mass Effect or even other works should be followed.
Finally, I agree with the points about
Halo and
Starship Troopers, but I think that only strengthens my arguments further. That is, one can envision a post-Nemesis
Trek that tries to deal with a coming catastrophe related to an "alien astronaut" backstory (similar to
Mass Effect or even
2001, and reminiscent of the first
Star Trek feature
), which involves investigation by military teams (a la
Starship Troopers or even
Aliens), political intrigue and conspiracy (
Mass Effect,
Halo, Aliens, and even reminiscent of backstories concerning Khan) that have to use more advanced technology (a la
Halo and
Mass Effect, and dealt with in numerous
Trek episodes but only in one or a few episodes).
Remove all references to
Mass Effect in what I wrote and the violation of that general rule remains.