Let's see,
- Valkyria Chronicles (I'm 3/4 through it)
- Mirror's Edge (1/3 done)
- Fallout 3 (barely started it)
- Metal Gear Solid 4 (haven't started it yet)
- Grand Theft Auto 4 (i'm halfway through my second completion of the game)
- NHL '09 (haven't played it in a while)
- Little Big Planet
- Motorstorm: Pacific Rift (online multi-player kicks ass)
I will most likely also play Ratchet & Clank: Tools of Destruction (and Quest for Booty) before R&C2 comes out. I've already completed R&C four times so far.

Oh and I also plan to play through Uncharted before U2 is released. That'll be like the fifth time I finish the game.
There are also titles that I might play every once in a while like Wipeout HD, Pixeljunk Eden, and Lego Star Wars.
And this isn't even counting all the new games coming out 2009, like Heavy Rain, The White Knight Chronicles, and Final Fantasy XIII (hopefully). Besides, who knows what else is gonna be good in 2009.

There's a ton of stuff coming out for the PS3 so I definitely won't be bored.