For me the Typhon Pact series is the bridge between David Mack trilogies. OK, that was an attempt at humor.
Actually, like the Destiny trilogy these books cover activities on all the main vessels, Enterprise, Titan, and Aventine. I'm not sure if the Defiant appears (I haven't read them all). They use characters from TNG, DS9, and VOY. They use cultures created or modified in ENT.
Is the activity of these exploration? No. They are action/adventure/romance stories. Read them if you want to understand about these fringe cultures that are being presented as "the newest threat to Federation security", or you care about who is having who's baby, or you want to know what "little people" the writers have made up (like half-this/half-that "new Starfleet" teens), or you want to know which bridge officers have which jobs now, or you want to know what would bring Sisko out of retirement. I am reading them for background for future novels.
But the Titan's mission of exploration? Again, I haven't read them all YET, but it really seems that mission got scrapped. I would like to be wrong. Maybe someone who has read them all will reassure me, but they don't seem to be seeking out new life or new civilizations. They only seem to be expanding on known civilizations, and sometimes even de-mystifying things that should have stayed mysterious, like the Breen.