I've been meaning to post my thoughts about this, but keep forgetting. Six episodes in, and I'm still really enjoying it. It is both a very faithful adaptation of the source material, and yet isn't slavish to it.
One of the changes in Molly, other than her age, is that her parents were killed when she was very young under mysterious circumstances. She was adopted by Gert's parents and the two were raised as sisters. Not only does this declutter the already big cast, it lends a little more mystery to the source of Molly's powers. Obviously, Molly Isn't a mutant in the show, so that brings up a lot of questions as to the source of her powers. I have a feeling that Gert's parents know the answers to those questions, as they seem to also know what happened to Molly's parents.
Instead of Chase being a dumb jock who uses tech created by his father, they made him a smart jock who creates his own tech. Somehow, I find this to be a more interesting variation on the character.
Gert's parents aren't time travelers, and Karolina's parents aren't aliens, and the Staff of One seems to be simply advanced science (which, of course, is what magic is supposed to be in the MCU.)
But, despite the changes, the show looks and feels like The Runaway should feel, and all the characters are true to who they're supposed to be.
I just wonder when they are going to, you know, run away? I have a suspicion that they're not going to actually run away until the end of the first season. If I recall correctly, that would have the first season more or less adapting the first 6 issue arc.
Interestingly, there has not been a single reference to the larger MCU whatsoever. This show could just as easily exist in its own universe and no one would be the wiser.