We'll see. It would have to be a pretty clean break from the original characters to avoid getting too bogged down.
Don't count on that; the MCU way is to dump as many intrusive rather than subtle Easter Eggs and hooks for other movies as possible, so no story is ever truly independent enough.
				

 I liked em. I just wish more backstory had been told before the Main Events, though. But I see how that did not affect the films bottom lines.