Han and Chewie?
Originally wrote that as a joke, but it might be a interesting "base template" for a Star Trek universe show. Rub off enough of the serial number so Disney doesn't get irate.
Close buddies/partners, small ship, adventure, no Picard-verse lectures, light grey level ethics.
Glue on a little Firefly, There are Federation core worlds where everything is fantastic, but outside this core the majority of the Federation is more getting by. Varies significantly from planet to planet.
Han and Chewie fly through the underbelly of utopia. No questions asked. Smuggling goods and people. Moving things that are legal (and cheap) on one world, illegal (and profitable) on another.
No death sticks of course.
Art works of questionable ownership.
Containers of Baku metaphasic particles.
Carrying spy's, revolutionaries, mercenaries, people who don't exist, wiving settlers, back channel ambassadors.
And the occasional beautiful princess bent on overthrowing the Federation.