He saw science fiction as a way to focus on stories about issues he wanted to tell, that could be disguised enough to get past the network censors.
Following Rod Serling's lead there.
With shows like The Defenders, East Side/West Side, Slattery's People, and The Bold Ones all on the air at some point in the sixties, the threat of network censors against thoughtful, relevant stories, especially by Roddenberry, but also by Serling, has always struck me as a tad exaggerated.
Marc Scott Zicree's Twilight Zone Companion discussed Serling's troubles during the production of "Patterns" for Kraft Televison Theatre; there was more than a hint of latent antisemitism exhibited by the sponsors and the network. Serling, as you can well imagine, liked to write, so keep this mind if you click on The Rod Serling Foundation's presentation of his introduction to a collection of his teleplays.
I can't speak for the rest of your referenced shows, but East Side/West Side was such a frustrating experience for George C. Scott that he vowed never to return to commercial network television. Harlan Ellison, too, is famous for his criticism of television censorship (and not just that one episode), and it is not surprising that he preferred science fiction for the reasons alluded to by both Serling and GR.
As with most of what GR said, a fair amount of circumspection is required; and perhaps Serling, too, was overly sensitive. Still, Scott and Harlan Ellison were neither shrinking violets nor were they afraid of a fight, yet both found TV in the 1960s confining.
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