I always thought a mix of organic and mechanical shooters would make most sense. Like, Peter could develop a web-secreting gland on his back, and then he'd figure out a way to dissolve the web into liquid and fire it with wrist cannons that possibly have tiny mechanical spider legs around the tip that weave it into different shapes as it's coming out.
More "plausibly", the super spider that bit him was also infested with nanobots that monitor/repair its volatile DNA. The bots start performing the same function in Peter, he figures out how to reprogram them, and one of their new functions actually becomes guiding the liquid web into whatever shape Peter imagines, and later making it disappear.
More "plausibly", the super spider that bit him was also infested with nanobots that monitor/repair its volatile DNA. The bots start performing the same function in Peter, he figures out how to reprogram them, and one of their new functions actually becomes guiding the liquid web into whatever shape Peter imagines, and later making it disappear.