While I fully expect some people to pull a "he was only joking" despite the utter lack of any evidence to back it up, it's now canonical fact that Time Lords can change sex when they Regenerate.
So I guess the only question left is, who do they cast first? I'd be partial to Minnie Driver myself.
So I guess the only question left is, who do they cast first? I'd be partial to Minnie Driver myself.