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The transporter copied over the common DNA of all humans to save power, per Geordi's claim in Picard S3 (this is what the changelings sabotaged to turn all humans who transported over into Borg, and even aliens like Bajoran Miura so presumably known alien species DNA was in the templates as well). Since Picard's Borg alterations required severe changes like telepathic links etc. to the collective that are beyond any human, it would likely be DNA changes well beyond the 1% or whatever "normal" differences among humans. Such a drastic DNA alteration to the very core of a human being would probably be "repaired" the moment Picard was transported after assmilation