I'd remake DS9 as "Star Trek: All Ferengi, All the Time". When the Cardassians left Bajor they sold Terok Nor to the Ferengi who stuffed it full of their own people. Avery Brooks would return as the Federation ambassador and only human on the station who has to deal with the Ferengi's zany schemes week after week.
And then, to cover all genres, in addition to my gritty HBO drama about Cardassian-run Terok Nor and your sitcom about the Ferengi-run Deep Space 9, we can make yet a third remake: a pro-wrestling show about a Klingon-run DS9 that would consist entirely of a Klingon version of WWE fights, interspersed with scenes of heavy drinking.
What? WWE is Science Fiction! Ask the SciFi channel.