If we take what's onscreen in TAS as (mostly) visually accurate then the Enterprise has more than one type of (di)lithium crystal on board, which presumably perform different functions. We're all familiar with the paddles and natural crystals which function as plot devices in various episodes, but in
The Teratin Incident there's also at least 6 larger crystals housed in a large glass structure in the middle of an engineering room somewhere (Geoffrey Mandel's cutaway puts them in the nacelles):
Unlike the smaller crystals & paddles who often seem to have the role of power generators/converters in the episodes where they're featured, these bigger crystals are explicitly called out as being crucial in the the M/AM reaction. If they're in the nacelles then this makes even more sense! The dialogue below shows Scott talking about dilithium in two distinct areas of the ship:
SCOTT: Engineering. No casualties, Captain, but trouble aplenty with the engines. Every dilithium crystal connection's smashed in the warp engine circuitry. We're trying to bypass them now.
KIRK: What about main circuits?
SCOTT: Well, you have to see it to believe it, sir. Those big crystals in there have come apart. Each of them unpeeling like the rind of an orange.
That situation seems unusual as it seems rare if not unheard of for the "big crystals" to fail - they are different somehow. Perhaps a combination of single function but larger and therefore more robust, happy to keep regulating a M/AM reaction for years at a time so long as no-one messes with them.
The smaller paddles which convert main power for deflectors and weapons etc are more versatile but also more fragile and so require re-energising or swapping out sometimes, be that with paddles or natural crystals.