Exactly, it could twist, turn and incorporate just about anything you wanted from Trek, all it is is a premise for a series, you could still have your main character(s) going on a mission into the unknown somewhere to complete and objective of some kind, protecting the prime directive etc - hell how many episodes down the years have seen our heroes have to blend (sometimes even be surgically altered) into an alien culture to observe them for example? It could incorporate the best of TOS/TNG and DS9.
After STID highlighting of S31 I think it could be a very interesting way to go, just plonking yet another crew on another starship and have them explore the galaxy has been done to death in my opinion, this would be a way to follow on from these films once they've done the third one, and could be a cutting edge that a new Trek series would need in what's let's face it, a crowded marketplace these days. Think of all the modern day social commentary that could be included - corruption, rendition, spying, a new cold war to explore, and thats just from the Federation side of things - it could be amazing...