I watched the episode. They seemed a bit too much focused on launch and landing the plane and how difficult it's supposed to be. Landing on two wheels, big wing span etc. I found it a bit odd since, if you don't take into account poor visibility from the cockpit, U-2 is basically just a big glider with a jet engine attached. And we do have gliders that approach the wing span of a U-2: https://en.wikipedia.org/wiki/Eta_%28glider%29
The real problem flying U-2 comes from a phenomenon called "coffin corner". What it means that the higher you go, the smaller your operational envelope will get. Your stall speed, the minimum speed to required to maintain level flight, will go up and the speed for critical Mach number (basically the airflow will start to go supersonic around the wing and it will cause loss of lift) will come down as the speed of sound is slower at higher altitudes. For U-2 the speed difference is around 5 knots at cruising altitude. You go too slow and you fall out of the sky or you go too fast and you will fall out of the sky. Hence the term "coffin corner". This makes turning the plane pretty dangerous, since one wing can reach the critical Mach, while the other wing will stall, if you screw things up.
The real problem flying U-2 comes from a phenomenon called "coffin corner". What it means that the higher you go, the smaller your operational envelope will get. Your stall speed, the minimum speed to required to maintain level flight, will go up and the speed for critical Mach number (basically the airflow will start to go supersonic around the wing and it will cause loss of lift) will come down as the speed of sound is slower at higher altitudes. For U-2 the speed difference is around 5 knots at cruising altitude. You go too slow and you fall out of the sky or you go too fast and you will fall out of the sky. Hence the term "coffin corner". This makes turning the plane pretty dangerous, since one wing can reach the critical Mach, while the other wing will stall, if you screw things up.