I’d be lying if I said I’m entirely sold on this idea, but it has potential
Firstly – crew evaluation.
The CO would be human, and have a strong grounding in engineering.
There really isn’t anything there to find interesting. What is it that distinguishes this CO from Kirk, Picard, Sisko, Archer, or any other commanding officer?
The XO would also be human, but be female, and have experience in tactical tasks.
Has potential but again there’s nothing substantial here to grasp onto.
The CMO would be a hologram, but fitted with an internal mobile emitter, similar to the one the Doctor had in Voyager.
… So in other words, just another Doc? Unless you made the character female this seems like just a rehash of an already existing character. A hologram with a different position aboard the ship seems like it would offer more depth.
The Security/Tactical officer would be Andorian
I like the idea of having a ‘blue head’ as a main character. Andorian. Bolian. Whatever. This character seems like the strongest link mentioned.
Whilst the flight controller is Tellarite.
Strange but I like this too.
Moreover, there would be no ship's counsellor as a principal character
Why? Does this mean there would be counselor at all? Or just not one who would regularly be featured?
The chief engineer would also be the Ops officer, since these roles largely overlap, and require the same skill sets/competencies to perform. In this case, the chief engineer would be present on the bridge to a large degree, and have a team lead (who is not often seen on screen) to manage things in the Engineering section when he she (,i.e. the chief engineer) is not present there.
Another idea I like. If you gave the team lead a recurring role such as that of Reginald Barclay (always on board, just not always seen) I think this could be interesting.
Concerning your ship…
Too much transwarp is not a good thing, but it could be used to good effect providing you have it as an experimental type thing, which is what seems to be suggested. Maybe have it used sparingly in the beginning of the series but more frequently as the series progresses. This would receive a certain amount of criticism from some members of the audience but so long as they remain a minority that’s not a problem.
Done right transwarp could add an interesting edge and provide more uncharted space for exploration.
Finally…
Humans as the enemies
Going back to the very beginning of this thread I agree strong characterisation, talented actors, and varying degrees of conflict (yes I paraphrased) are the best elements of Star Trek. However, I’d add symbolism between the species as another. Starfleet is the United Nations and each species represents another member of the World Government, as another worthy element.
Humans as the enemies doesn’t really work on that scale, unless you consider using them as a token for self reflection. What would we be like if we’d been raised in a different environment? Under a different chain of belief? Does the society we know hinder our progression or has it impacted us for the better?
If Character A grows up in the city surrounded by family, friends, various forms of luxury and entertainment, etc and Character B grows up as a solitary wild man of the forest what happens if both characters happen to encounter one another? How do they compare?
Or what if the humans on the other side of the galaxy are less comparative to humans of Starfleet and more comparative to humans of the present day or mirror universe?
As mentioned at the top of this post overall I believe this idea has potential, but also leaves room for improvement.