Well, some tweaking would probably be necessary as it is with most adaptations. For instance, a straightforward linear telling of the events probably wouldn't be the best way to go. Maybe they could have a split story format, with your cast of regular recurring characters that may be in the later days of the events, while the other half of the story tells the great historical events of the distant past in a way that's pertinent to the main story, with a constantly changing cast.
I realize as I read that back to myself, that I'm thinking of something similar to the format of Arrow. Except the flashbacks would command equal screen time as the main story, and hopefully not be as meaningless as the Arrow flashbacks tend to be.