Julian Bashir: Still serving as CMO of Starbase Deep Space 9. Is the continuing subject of recruitment/manipulation attempts from Section 31. Was recruited by Starfleet Intelligence in 2382 to go under cover at a Breen shipyard in order to destroy stolen Federation slipstream schematics and a prototype Breen slipstream-capable ship. This mission reunited him with Sarina Douglas, who has joined S.I. in the meantime; they rekindle their romance, while Bashir ends up committing what may be some war crimes in the course of the mission. Unbeknownst to him, Douglas had herself been recruited into Section 31, and initiated their relationship as part of Section 31's plan to break down Bashir's emotional defenses and bring him into the fold. However, Sarina told him of Section 31's plans, and seems to be genuinely in love with him. Sarina was briefly suspected of planting the bombs that led to the destruction of Deep Space 9 as part of a rogue Typhon Pact operation, but Bashir proved her innocence. Both remained with the DS9 crew after it was re-stationed to Bajor while a new station was constructed.
Jadzia Dax: Still dead.
Jake Sisko: Went on a journey to try to find his father after he was taken by the Prophets, and ended up as a crew member aboard the Gamma Quadrant freighter the Even Odds. Helped rescue former Kai of the Bajoran Church Opaka Sulan before returning to the Alpha Quadrant, and helped discover the Ev'oq. Subsequently met and married a Bajoran woman named Azeni Korena (the same woman he had married in the alternate future of "The Visitor"). Remains a writer and journalist.
Miles O'Brien: Taught at Starfleet Academy for a year before transferring to Cardassia Prime because of his wife's job. Keiko had become head of the Andak Project, an initiative co-funded by the Federation to try to restore Cardassia's agricultural base. O'Brien worked with the Starfleet Corps of Engineers reconstruction projects, and he and Keiko raised Molly and Yoshi on Cardassia for several years. Has since transferred to Bajor to help design and supervise the construction of the new Starbase Deep Space 9.
Quark: Still spinning those daboo tables. Was initially terrified that the UFP's socialist economy would ruin him once Bajor joined the Federation; his brother Rom solved this problem for him by appointing him Ferengi Ambassador to Bajor, and arrangements were made to turn the bar into a Ferengi diplomatic mission: Quark's Bar, Grill, Embassy, Gaming House and Holosuite Arcade. Immediately began running a similar operation on Bajor when DS9 was destroyed; will probably run a similar operation on the new Deep Space 9. Is in a relationship with Captain Ro Laren.
Kira Nerys: Served as commanding officer of Deep Space 9 throughout 2376 following Sisko's disappearance. Was ex-communicated from the Bajoran Church after leaking some "heretical" prophecies unearthed a B'hala that just happened to be accurate. Joined the Federation Starfleet and received a commission as captain following Bajor's admittance to the Federation. Was brutally attacked by the mind-controlled Jem'Hadar observer Taran'atar, who stabbed her through the heart, and nearly died. Dr. Bashir replaced her heart with an artificial one. Suffered a prophetic vision while in a coma about the coming of the Ascendants, and Bajor's need to find allies for this conflict. Then the editor of the book series was laid off, and the new editor decided to skip this arc to bring the DS9 books to the same years as the TNG and VOY books, so we missed what happened here. But we know that in 2378, Kira left Starfleet to become a cleric of the Bajoran Church (having apparently be un-excommunicated), and eventually became a Vedek. In 2383, Vedek Kira hijacked a runabout and helped thwart a rogue Tal Shiar plot, but this had the side-effect of sealing the Wormhole. Kira seemingly died... or has joined the Prophets. We'll see yet.
Ro Laren: Survived the Dominion War and achieved hero status on Bajor for her efforts against the Cardassians in the Maquis, and then against the Dominion during the war. Moved back to Bajor and joined the Militia; was appointed Chief of Security aboard DS9 in 2376 following Odo's departure. Thanks to the influence of Captain Picard, as able to re-join Starfleet and keep her billet when Bajor entered the Federation. Continued to rise through the ranks, becoming first officer of Deep Space 9 under Captain Elias Vaughn subsequent to Captain Kira's resignation. Commander Ro became C.O. of DS9 following Captain Vaughn's transfer to the U.S.S. James T. Kirk; she was prompted to captain in 2383. Captain Ro retained command of her crew following Deep Space 9's destruction at the hands of a rogue Typhon Pact faction, and will retain command of the new Deep Space 9. Is in a relationship with Quark.
Gul Dukat: Still dead. But it turns out his first name was Skrain. Also, he was keeping the real Illeana Ghemor (the Cardassian the Obsidian Order tried to trick Kira into thinking she was in that DS9 Season Three episode), who had been surgically altered to look like Kira, as his personal sex slave when he was alive. Just when you thought he couldn't get any creepier!
Damar: Still dead. And his first name was Corat. Now venerated as a patriotic hero on Cardassia.
Rom: Still Grand Nagus of the Ferengi Alliance. Has instituted numerous progressive reforms. Was almost overthrown in a coup that would have proven he'd violated a contract, but was vindicated by his brother Quark. He and Leeta had a child in 2376. Under his Nagushood, the Ferengi Treasury Guard joined the Federation's expeditionary force against the Borg and lost many ships; the Ferengi Ambassador to the Federation also agreed to hire out Breen privateers away from the Tholian Assembly, preventing them from seizing the crisis of the Borg Invasion to annex Federation border systems. Grand Nagus Rom later had the Ferengi Alliance join the expanded Khitomer Accords after the formation of the Typhon Pact.
Ishka and Zek: Still married. Serving as unofficial but influential advisers to Grand Nagus Rom. Would mostly prefer to give each other oo-mox, though.
Morn: Still talks too much.
Brunt: Still trying to thwart the efforts of Ferengi Progressivism, and still getting his ass kicked for it. Was behind the unsuccessful attempt too unseat Rom.
The Female Shapeshifter: Imprisoned for war crimes at Ananke Alpha, a maximum-security Federation prison. She is serving a life sentence, with the understanding that her sentence may periodically be re-considered or commuted due to the unprecedented nature and questionable morality of issuing a life sentence to a being who may be functionally immortal.
Gowron, Son of M'Rel: Still dead.
Martok, Son of Urthog: Still Chancellor of the High Council of the Klingon Empire. Was briefly deposed in a coup led by his illegitimate son when he returned to Qo'noS after the war; he defeated his son and returned to the throne when he recovered the Sword of Kahless. Was in constant conflict with a Klingon nationalist faction on the High Council led by Councillor Kopek, who had some viciously anti-Federation views. Tried to conquer Tezwa as retaliation for their destruction of a Klingon fleet sent to back up the Enterprise's attempt to negotiate a settlement for Tezwa's attempt to seize Klingon colonies, but was thwarted when the fleet was remotely disabled and the Enterprise secured the surrender of the Tezwan government first. This politically compromised both him and Worf, as it was an open secret that Worf had obtained the codes. Was in office when Emperor Kahless II chose to de facto abdicate the throne following his disappearance. Persuaded the High Council to support the Federation during the Borg Invasion and personally led the defense of Qo'noS from the invading armada aboard the I.K.S. Sword of Kahless. Was very nearly killed. Following the devastation on Qo'noS, Chancellor Martok has relocated the Klingon government to Ty'Gokor. Was also in office when the Defense Force destroyed the Kinshaya homeworld. Has lost the last of his family following a Kinshaya attack.
Keiko O'Brien: Headed up the Andak Project to restore Cardassian agriculture --even in the face of terrorist attacks.
Kassidy Yates: Was still captaining the S.S. Xhosa and living on Bajor. Was one of the few not aboard the Xhosa when it was destroyed during the rogue Typhon Pact attack on DS9. Reconciled with Sisko.
Michael Eddington: Still dead.
William Ross: Continued to serve as influential admiral for several years following the Dominion War. Flagship was the Prometheus-class U.S.S. Cerebus immediately after the war; recruited Captain Montgomery Scott to serve as overall commanding officer of the Starfleet Corps of Engineers. Participated in Starfleet plot to force Federation President Min Zife of Bolarus out of office when his war crimes were uncovered but could not be publicly revealed without provoking a war with the Klingons. Unbeknownst to the other members of this conspiracy, Ross was forced to allow Section 31 to assassinate Zife immediately after his resignation. Was pressured to run for president himself in the subsequent election, but refused. Endorsed Governor Nanietta Bacco of Cestus III instead, and then served as Starfleet liaison to the President for her first year of office. When President Bacco discovered that President Zife had been assassinated, she mistakenly believed Ross had murdered Zife himself. Ross allowed her to continue believing this, concluding that she herself would be assassinated by Section 31 if she were to learn of their existence or their role in Zife's death. Agreed to Bacco's deal to retire from Starfleet and never exercise any political influence or power again in return for a Trill journalist keeping Zife's assassination a secret. Retired in 2380.
Vic Fontaine: Still croonin'.
Elim Garak: Moved back to Cardassia following the war. Began living in the ruins of the estate of Enabren Tain, former head of the Obsidian Order and his illegitimate father. Began to attract public attention due to his creation of numerous abstract memorials out of the ruins of the estate. Was courted by both the fledging Cardassian democracy movement and the conservative faction known as the "Directorate;" chose to support the democrats, and became an influential adviser to Alon Ghemor, the new Castellan of the Cardassian Union (Cardassian head of government). Eventually served as Cardassian Ambassador to the United Federation of Planets under Castellan Rakena Garan. Persuaded a Federation court to recognize Federation citizenship for Rugal Pa'Daar, and agreed to the Cardassian Guard joining the Federatin's expeditionary force at the Azure Nebula during the Borg Invasion. Gives President Bacco the creeps.