Their last game was an open world third person action game, so they have done open world games before. How many Insomniac games have you played? Both the Spyro and Ratchet series are some of my absolute favorite games of all time, and I enjoyed the first Resistance game, although not as much as the Spyro and Ratchet games.
The bits I've played isn't bad, but there is a difference between Ratchet & Clank and an open world Spidey game. They've never really done open world games, because Spyro, R&C, etc weren't open world, they had large open areas but it wasn't even Witcher 3 or Dragon Age Inquisition levels of open world.
I've liked Mr. Negative in the comics, and I love the fact that they're actually focusing the game on of the newer villains who hasn't been adapted a lot, instead of one of the older villains who's been in pretty much every Spidey game ever.
I'd like lesser known villains. Give me Mysterio, Kraven, Shocker, Rhino, Hammerhead, Tombstone, etc. Heck, I genuinely consider Mysterio to be my #1 wanted villain in a Spidey movie, so he'd be great in a game. I just hate Mister Negative. he's the easiest Spidey villain to defeat (just wear gloves or catch him from a distance, he's not even a match for z-list heroes and his power is terrible) and his power sucks.
Plus, I've had a huge grudge against him out of universe because the writers made Cloak and Dagger his slaves for over a year (in real time, not comic time), obviously forgot they did it because basically no one uses them any more, then had to quickly BS their way to curing them because they needed the heroic versions back. Negative is basically just a lazy, boring rip off of Purple Man but weaker. Easily my second least favorite Spidey villain the (#1 worst is a tie between the older and the recent versions of The Jakal).
I love the idea that we'll get to place as MJ, and I would love to be able to play as Aunt May. Even if they aren't big action sequences these days games like this can still find a lot of interesting things with characters like this. I've actually found that some of the sequences with characters like them can actually be some of the most memorable parts of the games since they are so different, and because they tend to be some of the more story focused sequences with some of the most significant developments.
I almost always hate games that take away from the main action with an alternate character with a massively different playstyle. Like action games that put painful stealth characters into the game. It almost never works.
They were just talking about how she's a reporter in this game, they never once mentioned her being a reporter in any other version. I think it's a great idea myself, it's great way to give her a more active role in the story than just Spider-Man's girlfriend.
Then they should have either used Betty Brant or thought of something that fits the character. But, its unimportant since its not really MJ, Peter never knew MJ as a teenager. Its a version of a character that has literally nothing in common with the actual one except the name.
You do realize that probably 90% of Spider-Man adaptations at least start with him as a teenager, including the Raimi movies, the Amazing movies, the MCU, the Ultimate Comics, the Ultimate animated series, and the current Spider-Man animated series.
He was a teenager for about 10-20 minutes in the Raimi movies, and all the other things you listed are terrible. The Amazing films sucked, Homecoming is the first truly awful MCU film (and in the MCU in general the only reason its not the worst is that Iron Fist is longer and I'd take 2 hours of shit over 12ish), the Ultimate animated series is literally the worst Marvel cartoon ever produced (which is saying something), the current cartoon is bland junk, and Ultimate Spider-Man comic is the single most overrated comic produced in my lifetime (although its not terrible, just boring and inferior to most of the good spider-man comics).
The two best adaptations, the Raimi films and the 90s cartoon( even with its flaws the 90s show still one of the more popular Spidey adaptations) he's an adult the vast majority of the time. He's also been an adult in the main continuity since 1965 and he's survived and even thrived more over the years as an adult then as a teen.