My main concern is that although MU Georgiou is fun, and Yeoh is a great actor, Trek fans won't be down with such an unsympathetic protagonist. IMHO the actions she took in Season 1 make it hard to even swallow her as an antihero. You'd need to pair her up with a "straight man" who served as the conscience of the audience or something. Otherwise, have her undergo some sort of redemption arc. Female antihero is an infrequently done trope however, I must say.
I think Trek fans will be most upset with how much of the dark underbelly of the Federation we will see though. I mean, the series will almost literally have to be constructed based upon previously impossible things in Trek canon having unofficial Starfleet sanction. Hopefully she mostly sticks to foreign operations, rather than doing much domestically. I really don't think people want to see a series where Georgiou is on Earth extorting, bribing and blackmailing minor government functionaries on the orders of superiors for example.